Detect and exclude HPP with an ordinary blood test

Hypophosphatasia (HPP) is a potentially life-threatening, systemic, inherited metabolic disease caused by impaired activity of the enzyme alkaline phosphatase (ALP). Hypophosphatasia can cause skeletal deformities, early loss of teeth and repeated fractures and/or symptoms from several of the body’s organs.

SYMPTOMS AND CONDITIONS
ASSOCIATED WITH HYPOPHOSPHATASIA

COMMON SYMPTOMS AND CONDITIONS THAT
CAN BE CAUSED BY HYPOPHOSPHATASIA READ MORE

THE ALP CALCULATOR
– DIAGNOSTIC TOOL

LOW ALP ACTIVITY KEY TO DIAGNOSIS READ MORE


IMPORTANT DIFFERENTIAL DIAGNOSES

IMPORTANT DIFFERENTIAL 
DIAGNOSES/CONDITIONS READ MORE
Mornet E. Best Pract Res Clin Rheum 2008; 22: 113-127. | Mornet E et al. Ann Hum Genet 2011; 75: 439-445. | Rockman-Greenberg C. Ped Endocrinol Rev 2013; 10 (Suppl 2): 380-388.
Rodriguez E et al. Pediatr Pulmonol. 2012; 47 (9):917-922 | Whyte MP. Ann N Y Acad Sci 2010; 1192: 190-200.


Last Updated: 22 June 2015
Film on the disease mechanism behind hypophosphatasia

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